KPV is a three-amino-acid anti-inflammatory peptide fragment of alpha-MSH, studied for gut and skin inflammation. It is compounded and not FDA-approved as a finished drug. Ivologist prescribes it as capsules or within the KLOW combination vial after a medical telehealth consultation.
KPV Peptide
A physician-supervised KPV protocol for gut and skin inflammation. KPV is a three-amino-acid fragment of alpha-MSH studied for targeted anti-inflammatory action, available as capsules or within a combination vial. Programs include an online provider consultation, medication, supplies, and ongoing clinician guidance. Eligibility is determined by a licensed healthcare provider.
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- Clinician consultation
- Peptide medication
- Free shipping
- May require labs
One-time payment, not a subscription. Up to 3 cycles per year. A cycle is the program length; your provider decides whether treatment is right for you and sets your dose, schedule and duration. We do not offer clinical trials. Individual results may vary.
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Studied in lab and animal research for gut-lining inflammation, including IBS and colitis pictures. No completed human trial as a single agent.
Researched, mostly in the lab, for inflammatory skin, flares and redness.
An oral option — capsules, nothing to inject.
Integrates with broader care as the anti-inflammatory arm of KLOW and Quell.
Clinician-guided treatment, prescribed after a provider evaluation.
All treatment plans require medical evaluation and approval. Individual results may vary.
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Personalized Intake
Tell us about your health, goals, and history through a secure intake questionnaire.
Clinician Review
A licensed clinician reviews your information and determines what's right for you.
Diagnostic Lab Testing
Baseline lab work checks your health markers before any peptide is prescribed.
Clinical Evaluation
A provider reviews your labs with you in a live video visit and confirms your suitability for peptide therapy.
Medication Delivered
Your prescribed medication is prepared by a partner pharmacy and shipped to your home.
Ongoing Support
Your progress is monitored with follow-ups and adjustments as needed.
Built around 12-week cycles
Peptide programs are sold in 12-week cycles (about 3 months). You can buy one cycle or a bundle of up to 3 cycles up front, with a maximum of 3 cycles per year.
Labs and a provider consultation are required.
Every peptide program starts with lab work and a live consultation with a licensed provider before anything is prescribed.
- Lab panel includedOne cycle at a time
- Bundle of 2 · save 7.5%
- Bundle of 3 · save 12.5%
- Clinician consultation & follow-up access
- All peptide medication for the cycle
- Shipping to your door
- Injection supplies & dosing guide
Peptide therapy
Not sure which peptide program is right for you?
Talk it through first in a free 15-minute provider consultation. A U.S.-licensed provider will go over your goals and health history, explain how the programs work, and help you decide whether one is right for you before you commit to a cycle. There is no obligation to start treatment.
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Understanding KPV and inflammation
How a melanocortin fragment quiets an overactive local immune response. Learn how clinician-guided KPV may support gut and skin inflammation without broad immune suppression.
Understanding KPV & Inflammation
Learn about KPV, how it works inside gut and skin cells, and how clinician-guided therapy may fit your care plan.
The Physiology
Proposed Melanocortin Anti-Inflammatory Pathway
α-MSH fragment (KPV) → PepT1 transport → NF-κB blocked → less inflammatory signalling
KPV is the three-amino-acid tail (lysine–proline–valine) of alpha-MSH, one of the body's own anti-inflammatory hormones. It carries the anti-inflammatory activity without the pigmentation effects of the parent molecule.
In laboratory studies, inside gut and skin cells it blocks NF-κB, the switch that drives the inflammatory cascade — a targeted action rather than broad immune suppression. The transporter that carries it into the gut lining, PepT1, becomes more active where the gut is inflamed, which is why researchers expect KPV to concentrate where the problem is.
That mechanism is well described in laboratory work. KPV has not yet been properly studied in people as a single agent, and your provider will say so before you consent.
Symptoms
Symptoms & Signals
KPV is considered when patterns like these are present:
Experiencing multiple patterns may warrant clinician evaluation.
Who Is It For?
Who May Benefit from KPV?
KPV may be considered for adults who are:
Clinical evaluation is required. Your eligibility will be determined by a licensed provider.
Capsules vs Injection
KPV Capsules vs Injectable KPV
Two routes to the same peptide — your provider chooses.
Oral capsules
500 mcg capsules taken daily; nothing to inject.
- Designed to reach the gut lining (PepT1 transport, lab studies)
- The needle-free option — the KPV in the Quell program
- Stored at room temperature
Injectable (KLOW combination vial)
KPV combined with BPC-157, TB-500 and GHK-Cu in one vial.
- •One injection routine for the KLOW blend; the blend itself has not been studied
- •Chosen when there is a musculoskeletal or skin-repair component
Route is a provider decision. A patient on both KLOW and Quell takes KPV by two routes — deliberately, never by accident.
Protocol
Protocol Philosophy
KPV is studied as an anti-inflammatory signal, so any response tends to build gradually over a cycle rather than overnight.
An example, not your plan. On this page KPV comes as daily capsules or inside the KLOW combination vial; your provider chooses the route. The 12-week cycle you choose is the program: clinician consultation, peptide medication and free shipping; labs may be required. It is not a dosing schedule; your provider decides your dose, how often and for how long.
Early Phase (Weeks 1–2)
Protocol begins and your baseline is recorded.
Adaptation Phase (Weeks 3–4)
Your body adjusts; no dramatic change is expected yet.
Progression Phase (Weeks 4–6)
Some people report easing symptoms. This is not guaranteed.
Assessment (Weeks 8–12)
Reviewed together against what you described at the start.
Responses vary by individual.
Research Findings and Limits
Research Findings and Limits
What KPV has been studied for, and the kind of study behind each:
Limits of the research. KPV's evidence is mainly laboratory and animal work, with no completed human trial as a single agent. No outcome is guaranteed.
Individual responses vary.
Designed for Safety. Guided by Clinicians.
- Targeted, not immunosuppressive — in lab studies KPV calms inflammation inside gut and skin cells rather than suppressing the immune system broadly
- Gradual, not instant — some people report easing around weeks 4–6, though this is not guaranteed, and your provider reviews at 8–12 weeks
- One peptide, one plan — your provider chooses the route and checks you aren't already taking KPV inside KLOW or Quell
KPV is excluded in pregnancy and breastfeeding, and your full medication list and any other programs are reviewed before it is prescribed
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The licensed providers behind your personalized care
Dr. Utkal Patel
MD, Internal Medicine
Critical Care Medicine
Samantha Alonso
Board Certified
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FNP-BC
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Board Certified
Internal Medicine
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MD, FCCP
Internal Medicine, Pulmonary & Critical Care
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MSN, RN, APRN, FNP-BC
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AGACNP-BC
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Integrative Health Practitioner
Health Coaching
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Integrative Health Practitioner
Health Coaching
Frequently Asked Questions
Get answers to commonly asked questions.
Yes. KPV requires evaluation by a licensed provider, who determines eligibility and the route — capsules or the KLOW combination vial — before anything is prescribed.
KPV is a three-amino-acid peptide (lysine–proline–valine), the active anti-inflammatory tail of alpha-MSH, one of the body's own anti-inflammatory hormones. It carries the anti-inflammatory activity without the pigmentation effects of the parent molecule and is studied for gut and skin inflammation.
No. KPV is compounded by a licensed 503A pharmacy and is not FDA-approved as a finished drug. Its evidence is mainly laboratory and animal work, with no completed human trial as a single agent.
In laboratory studies, KPV is carried into cells by the PepT1 transporter and blocks NF-κB, the switch that drives the inflammatory cascade. Because PepT1 is more active in inflamed gut lining, researchers expect KPV to concentrate where the inflammation is — a targeted action rather than broad immune suppression. It has not been properly studied in people as a single agent.
Your provider decides. Capsules (500 mcg to 1 mg daily) are designed to reach the gut lining directly and are the needle-free option; the injectable form comes inside the KLOW combination vial with BPC-157, TB-500 and GHK-Cu, chosen when skin or musculoskeletal repair is part of the plan.
Still have questions? Contact us